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The Kucherlapati Lab at Brigham and Women's Hospital focuses on human cancer genomics to understand genetic changes present in tumors, providing insights into the evolutionary history of cancer. The lab is involved in comprehensive studies of tumor genomes through initiatives like The Cancer Genome Atlas project in collaboration with institutions across Harvard. The emphasis is placed on utilizing whole genome sequencing to identify copy number alterations and structural changes in various cancers. One of the longstanding programs investigates the role of specific genes in human cancers, particularly colorectal cancer, through genetically engineered mouse models. Key genes of interest include Adenomatous polyposis coli (APC) and DNA mismatch repair genes such as MLH1 and MSH2, which are linked to hereditary cancer predisposition syndromes. The lab also explores the RAS-Map Kinase pathway's involvement in cancer and related genetic disorders, aiming to develop novel therapeutic approaches for these conditions.