Natasha Mhatre's research primarily focuses on the intersection of biology and physics, exploring acoustic vibratory communication in insects and spiders. With an interest in how morphology and the physics of dynamics influence sensory systems, Mhatre examines how these aspects enhance cognitive function in animals. By incorporating quantitative empirical research and a variety of theoretical modelling techniques, her work aims to provide insights into the behavior and communication strategies of animals in relation to their environment. Mhatre employs high precision vibrometry, neurobiology, and behavioral studies alongside tools such as finite element analysis and stochastic simulations to investigate these phenomena. Her integrative approach seeks to merge biological scales, considering everything from molecules to organisms in the context of ecology.