Gerd Blobel is an investigator at the Blobel Laboratory, Children's Hospital of Philadelphia. His research is focused on the fundamental mechanisms involving transcription factors, chromatin regulators, and higher order chromatin. He aims to discover the genetic and epigenetic mechanisms that can lead to new treatment modalities. A major aspect of his work revolves around developmental regulation and the beta-globin locus, which plays a critical role in diseases such as sickle cell disease and thalassemia. His lab employs molecular biology and biochemistry techniques combined with advanced 3C-based technologies and single molecule tracking to understand the mechanisms of nuclear architecture, epigenetic memory, and gene expression. His contributions to basic science discoveries have been recognized by the National Academy of Medicine.
Blobel Laboratory, Children's Hospital Philadelphia • Philadelphia, PA, USA
Investigates fundamental mechanisms of transcription and chromatin regulation.