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The Boerckel Laboratory at the University of Pennsylvania focuses on Developmental Mechanobiology and the mechanisms of tissue regeneration. Their research seeks to understand how mechanical signals influence embryonic development and utilize this knowledge to create innovative tissue engineering strategies. Core areas of investigation include the roles of mechanosensitive transcriptional regulators, particularly Yes-associated protein (YAP) and the transcriptional co-activator with PDZ binding motif (TAZ), in processes of mechanotransduction, morphogenesis, growth, adaptation, and repair. The lab actively develops new tissue engineering techniques to address complex injuries by employing engineered matrices and bioreactors to investigate cell mechanotransduction mechanisms. They use genetic mouse models to study the development of diseases and conduct experiments with mouse and rat models for repair and regeneration studies. Committed to diversity and inclusion, the lab emphasizes the importance of a supportive environment for all lab members, regardless of their backgrounds or personal characteristics.
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