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Heo Lab is dedicated to advancing nuclear mechanobiology and tissue engineering, developing innovative therapeutic approaches for musculoskeletal repair and regeneration. The multidisciplinary research team is committed to understanding the intricate interplay of biophysical environments and cell biology in the context of musculoskeletal tissue remodeling, encompassing development, disease, degeneration, and repair. The lab addresses fundamental questions by employing cutting-edge experimental techniques, such as Super-resolution Stochastic Optical Reconstruction Microscopy (STORM), to delve into the nanoscale regulation of cellular behaviors by biophysical cues. The aim is to manipulate the cellular microenvironment, opening avenues for innovative research in the field. Furthermore, the research elucidates fundamental mechanisms to translate findings into practical applications, particularly in engineering complex functional tissue constructs. To achieve this, Heo Lab utilizes fabrication techniques, including electrospinning and 3D bioprinting, pivotal in the realm of regenerative medicine. Overall, Heo Lab is committed to pushing the boundaries of knowledge in nuclear mechanobiology, tissue engineering, and regenerative medicine, aspiring to contribute to the development of innovative therapeutic strategies for functional tissue constructs that have the potential to revolutionize musculoskeletal repair and regeneration.
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