The Fischer Lab at Dana-Farber Cancer Institute focuses on the Ubiquitin Proteasome System and its role in various cellular processes implicated in human diseases. Through a combination of structural biology, cell biology, and high throughput biology approaches, the lab aims to understand the mechanistic principles that govern signaling within the ubiquitin proteasome system. This research leverages insights to propose and test new avenues for therapeutic intervention, particularly in the area of targeted protein degradation. The lab emphasizes a multi-disciplinary and highly collaborative approach to tackle fundamental questions in biology and pharmacology. Collaborations with the Center for Protein Degradation at the Dana-Farber Cancer Institute play a crucial role in the development of novel therapeutics, positioning the Fischer Lab at the forefront of drug development and biological study.