Dr. Manolis Roulis leads the research at Roulis Lab at the Perelman School of Medicine. His lab focuses on the tissue microenvironment and its role in diseases, particularly understanding the complex interactions among resident cell types, the immune system, and microbiota. The lab investigates how these interactions maintain homeostasis in mucosal barrier tissues and what happens when this balance is disrupted, leading to inflammation, fibrosis, and neoplasia. A particular emphasis is placed on studying various types of fibroblasts within the intestinal mucosa, each with unique transcriptional programs and functions. The lab is dedicated to uncovering the physiology of these fibroblasts in both health and disease, an area that remains largely unexplored.
Roulis Lab • Philadelphia, PA
Leading research on tissue microenvironment and its implications in various diseases.