Bin Tian is a molecular systems biologist whose research is centered on understanding gene expression regulated at the RNA level. His laboratory has uncovered the widespread phenomenon of alternative polyadenylation (APA) through bioinformatic and genomic approaches. This work has revealed multiple molecular mechanisms regulating APA, leading to distinct cellular consequences based on the regulation of APA isoform expression across diverse biological systems. Current research interests comprise the functional impacts of APA polymorphisms on disease risks in human populations, the specific stages of cancer development influenced by gene regulation related to APA, and the roles of APA in neurodevelopment and neurodegeneration. Tian's educational background includes a B.S. in Biochemistry from East China University of Science and Technology and a Ph.D. in Molecular Biology from Rutgers Biomedical Health Sciences. He established his research group in 2003 at Rutgers New Jersey Medical School, achieving the rank of tenured professor in 2014, before joining the Wistar Institute in 2020. His research contributes significantly to the knowledge of mechanisms affecting alternative polyadenylation and its implications for human health and disease.
Wistar Institute • Philadelphia, PA
Leads research in molecular systems biology focusing on gene regulation and alternative polyadenylation.
Rutgers New Jersey Medical School • Newark, NJ
Established and directed a research group exploring RNA biology and gene regulation.