Dr. Sheng Li’s lab develops AI-driven multi-omics approaches to investigate aging somatic mutations that reshape hematopoietic stem cells, driving clonal hematopoiesis leukemia. By integrating single-cell, spatial, and long-read sequencing, the lab uncovers epigenetic transcriptional programs influencing stem-cell aging and cancer evolution. The interdisciplinary team combines computational biology and translational genomics to transform large-scale data into actionable insights that advance precision medicine and improve human health.
Keck School of Medicine of the University of Southern California • Los Angeles, CA
Dr. Sheng Li conducts research in cancer biology and computational biology, focusing on hematopoietic stem cell mutations.