Jueqi Chen is a researcher at the University of Chicago, leading studies on host-pathogen interactions focusing on infections, pathogens, viruses, and bacteria. The lab is particularly interested in how these entities remodel host organelles, promote pathogenesis, and trigger host innate immune responses, along with exploring innovative therapeutic strategies for infectious diseases, inflammatory disorders, autoimmune diseases, and cancer. Recent studies have uncovered critical insights into bacterial toxins and their role in innate immunity, particularly how they can reorganize the trans-Golgi network (TGN) and activate the NLRP3 inflammasome. The lab also investigates novel membrane structures that assemble during SARS-CoV-2 infection, examining their implications for viral entry efficiency. Utilizing advanced techniques such as CRISPR technology, high-resolution fluorescence imaging, and mouse infection models, the lab employs a multifaceted approach to studying these complex interactions.
University of Chicago • Chicago, IL
Leads studies on host-pathogen interactions and innate immunity.