Edward N. Pugh, Jr. is a distinguished professor at the University of California, Davis, specializing in the mechanisms of phototransduction in rod and cone photoreceptors. His research focuses on understanding how these cells convert light into electrical signals, with a particular emphasis on mouse cone photoreceptors. Pugh's laboratory has pioneered several methods, including specific recording techniques for studying light-driven currents in single mouse cones, and has made significant contributions towards elucidating the functional co-expression of cone opsins. His work has resulted in valuable insights into cone opsin regulation and the development of mouse models, such as S-opsin knockout and knockin mice. For the past several years, Pugh's team has increasingly utilized two-photon imaging technology to study retinal function, overcoming the limitations of traditional imaging techniques. This innovative approach is enabling exciting advances in the understanding of retinal diseases affecting cone photoreceptors.