Dr. Tsirigos leads the Tsirigos Lab at the NYU Langone Grossman School of Medicine, focusing on computational genomics and precision medicine. His research has advanced our understanding of the role of chromatin organization in cancer, particularly in acute leukemia. Notable achievements include the identification of chromatin hubs as drivers of acute leukemia and the development of C.Origami, a deep learning model designed to predict cell-type-specific chromatin architecture. Dr. Tsirigos's work has also characterized the remodeling of 3D genome architecture in patients with relapsed leukemia. The lab investigates oncogenic signal transduction and epigenetic regulation, revealing how these factors can modulate leukemia-specific chromatin interactions. Dr. Tsirigos's computational expertise extends to the development of the HiC-bench platform for multi-parameter analyses of Hi-C/HiChIP data. He collaborates with the NYU Molecular Pathology Lab to develop molecular assays for actionable mutations in cancer patients, with efforts geared towards enhancing personalized healthcare through innovative research and technology integration.