Sin Yin Lim's research utilizes quantitative pharmacokinetics and pharmacodynamics (PK/PD) modeling approaches to improve pharmacotherapy. Her work emphasizes understanding and quantifying the impact of physiological changes and pathological factors on drug disposition, particularly in pediatric populations. She has employed mechanistically and physiologically-based PK, as well as population PK/PD modeling simulation approaches, to describe drug disposition and evaluate individualized dosing strategies for children. Currently, her research focuses on optimizing pain and sedation management in critically ill children. She is studying biomarkers and developing PK/PD models to help identify tolerance to opioid sedative therapy, aiming to reduce opioid exposure in children and avoid iatrogenic withdrawal syndrome.
University of Wisconsin • Madison, WI
Teaching and research in pharmacokinetics and pharmacodynamics.