Sarah Bondos is an Associate Professor at Texas A&M University Naresh K. Vashisht College of Medicine. Her research focuses on biophysical and genetic approaches to understand how proteins utilize unstructured regions to sense cellular information and respond by adjusting their function. Her lab has developed methods to purify Ultrabithorax, a full-length, active Hox transcription factor, providing a unique opportunity to investigate the role of intramolecular regulatory interactions in tissue-specific protein regulation. Bondos' team has revealed that Ultrabithorax can self-assemble into robust, extensible biomaterials that are biocompatible, thereby offering innovative opportunities for functionalization. These materials are being used to create biosensors and instruct vascularization in tissue engineering scaffolds. Bondos also investigates the tissue-specific regulation of protein function, focusing on the Hox transcription factor family and its influence on the development of various tissues and organs. Her lab explores the regulatory mechanisms involving the interactions within structured homeodomains and intrinsically disordered regions of Drosophila Hox protein Ultrabithorax, utilizing a combination of biophysical, cell biological, and genetic methodologies. Graduates from her lab have opportunities for training in the Medical Science PhD program and the MD/PhD program at Texas A&M.
Texas A&M University Naresh K. Vashisht College of Medicine • Bryan, TX
Teaching and conducting research in medical physiology.