Dr. Aaron Lebeau

Biography

Aaron LeBeau, PhD, is an Associate Professor in the Departments of Radiology, Pathology, and Laboratory Medicine at the University of Wisconsin School of Medicine and Public Health. His research focuses on the development of novel antibody-based molecular imaging probes and targeted therapeutics for cancer. His laboratory specializes in antibody phage display which enables the rapid identification of antibody fragments that target cancer-associated antigens using both human and mouse antibody libraries. The antibodies are coupled with radioisotopes to create positron-emission tomography (PET) and single-emission computed tomography (SPECT) nuclear imaging probes as well as radioimmunotherapy agents. LeBeau's laboratory has also established non-human single-domain antibody libraries derived from naïve camelids and nurse sharks to serve in next-generation antibody-drug conjugates and imaging probes for oncology applications. In addition to his extensive work in cancer, the lab is actively developing non-canonical neutralizing antibodies as imaging probes for beta-coronaviruses, including SARS-CoV-2. A native of Illinois, Dr. LeBeau completed his undergraduate studies at the University of Arizona, where he double majored in Molecular and Cellular Biology and Chemistry, along with a minor in Classical Art and Archaeology. He earned his PhD in Pharmacology from Johns Hopkins University School of Medicine and subsequently completed a postdoctoral fellowship at the University of California, San Francisco, focusing on antibody engineering and preclinical nuclear imaging. Dr. LeBeau joined UW-Madison in June 2021 after seven years at the University of Minnesota Medical School. His groundbreaking research has been recognized with awards from the Society of Nuclear Medicine and the Prostate Cancer Foundation.

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