Dr. Adam Nabeebaccus

Biography

Adam Nabeebaccus is an Honorary Consultant Cardiologist and Clinician Scientist based at King's College London. His research aims to understand the fundamental mechanisms underlying heart failure, which leads to improved insights into heart failure biology and therapeutics, ultimately enhancing the lives of those living with heart failure. His areas of interest include cardiac metabolism and pathological cardiac remodeling. He has pursued significant work on the role of the reactive oxygen species-producing signaling enzyme, NADPH Oxidase 4 (NOX4), in regulating cardiac metabolism. Nabeebaccus has demonstrated that NOX4 plays a crucial role in modulating the heart's response to stress, influencing the heart's ability to utilize carbohydrates and fatty acids during prolonged stress, potentially delaying the transition to heart failure. Notably, he identified the activation of an intermediary metabolic pathway called the hexosamine biosynthesis pathway (HBP) and its upregulation of GFPT1/GFAT1, which have cardioprotective roles. His current research focuses on the role of GFPT1 in cardiomyocyte response to pathological stress, utilizing in vivo physiological models to study GFPT1 functions in the failing heart alongside in vitro studies.

Research Interests

Experience