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Dr. Giacca's research investigates the effects of excess circulating energy substrates, particularly free fatty acids, on insulin action, secretion kinetics, and the implications for the pathogenesis of diabetes. His work primarily focuses on the role of energy excess in causing type 2 diabetes, atherosclerosis, and cancer. Dr. Giacca's laboratory utilizes glucose and fat infusions in rat and mouse models to determine the mechanisms by which excess nutrients oppose insulin action and stress pancreatic beta cells producing insulin, ultimately leading to diabetes. His team employs various methods, including cell tissue culture, glucose clamp techniques, and western blot analysis, to assess the effects of glucose and fat on insulin action, as well as their roles in atherosclerosis and cancer development. Dr. Giacca is dedicated to identifying targets for the prevention and treatment of type 2 diabetes, with a particular interest in oxidative stress and inflammation as key mechanisms in disease progression.
Department of Sociology