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Adrian T. Keatinge-Clay is a Professor in the Department of Molecular Biosciences at the University of Texas at Austin. His research focuses on Natural Product Biochemistry, particularly the use of modular polyketide synthases (PKSs) to design and engineer new pharmaceuticals. His lab investigates the chemical machinery involved in the biosynthesis of complex molecules such as antibiotic erythromycin and immunosuppressant rapamycin, which belong to a diverse class of molecules known as polyketides. The lab aims to understand the mechanisms and specificities of PKSs and to genetically engineer them to create libraries of derivatives of known polyketides, leading to the development of entirely novel compounds. Keatinge-Clay's research also explores the structural biology of PKS enzymes and their biophysics, aiming to elucidate the interactions between these enzymes and their substrates. This work is crucial for advancing the field of organic synthesis and promoting the use of PKS enzymes as biocatalysts in green chemistry applications.
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