Dr. Alan D Andrea

Biography

Alan D'Andrea holds the position of American Cancer Society Professor of Radiation Oncology at the Dana-Farber Cancer Institute. His research focuses on the molecular signaling pathways that regulate the DNA damage response in mammalian cells. He investigates the impact of disruptions to these pathways, particularly through germline and somatic mutations, which contribute to genomic instability and increased sensitivity to ionizing radiation in cancer cells. D'Andrea's primary area of interest lies in the molecular pathogenesis of human chromosome instability syndromes, including Fanconi Anemia, Ataxia Telangiectasia, and Bloom's syndrome. He has cloned thirteen Fanconi Anemia genes, which encode proteins that interact within a novel signaling pathway essential for maintaining genomic integrity. His ongoing research addresses the assembly and function of the FA protein complex, the mechanisms of monoubiquitination and deubiquitination, and the identification of novel interacting proteins within chromatin-associated complexes. Through his work, D'Andrea aims to elucidate the complex mechanisms that underpin cancer susceptibility and development.

Research Interests