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Aleksandar Necakov is an Associate Professor in the Department of Biological Sciences at Brock University. His research focuses on the Notch signaling pathway, a crucial system for cell-to-cell communication in multicellular organisms that ensures the correct formation of cell types at precise times and locations within the body. This pathway's defects are associated with various human developmental diseases and cancers. Recently, the understanding of the mechanisms that govern Notch signaling has grown significantly, especially concerning cellular genetic requirements and the process of endocytic trafficking, which is vital for the regulation of Notch signaling. By utilizing a combination of genetic engineering, high-resolution live imaging, and Optogenetics, Necakov's research employs Drosophila and human cell model systems. His lab's approach enables the investigation of the relationship between signaling and trafficking machineries while providing training opportunities for undergraduate and graduate students. The research aims to generate comprehensive data sets that pave the way for novel hypotheses about the regulatory architecture of Notch signaling in multicellular development.
This entry applies to the general Graduate Studies standard for departments such as English Language and Literature, History, Philosophy, and Sociology.