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Alessandra Chesi is an Assistant Professor in the Department of Pathology and Laboratory Medicine at the Perelman School of Medicine at the University of Pennsylvania. She specializes in the field of structural functional genomics. With an MSc in Physics from the University of Pisa and a PhD from the International School for Advanced Studies in Trieste, her research focuses on neurodegenerative disorders, particularly Alzheimer's and Parkinson's diseases. Dr. Chesi employs an integrated approach combining experimental and bioinformatic techniques to explore the genetics underlying human complex traits and to identify actionable target genes and molecular mechanisms involved in neurodegeneration. Her laboratory utilizes advanced genomic and epigenetic techniques, including Capture C, ATAC-seq, RNA-seq, and CRISPR/Cas9 to investigate the genetic variants associated with these conditions, with the ultimate goal of discovering novel drugs based on identified molecular targets. She encourages collaboration and rotation projects within her lab to further explore these critical areas of research.
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