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Alessandro Gardini is an Associate Professor at the Wistar Institute within the Perelman School of Medicine at the University of Pennsylvania. His research focuses on the transcriptional mechanisms that control cell fate choice and differentiation of human hematopoietic stem cells. Specifically, Dr. Gardini investigates genomic regulatory sequences, known as enhancers, to determine cell identity and specify blood lineages including monocytes/macrophages and granulocytes. His lab works to understand large nuclear multi-protein complexes such as Integrator and SWI/SNF, which are crucial for fine-tuning transcription and coordinating activation of enhancers with target promoters. His research projects delve into enhancer regulation, hematopoiesis, and leukemia, exploring how enhancer function and noncoding RNAs contribute to gene regulation and developmental processes. Additionally, Gardini examines the roles of chromatin remodelers like ARID1A in transcriptional regulation, particularly their effects on RNA Polymerase II activity in the context of human cancers.
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