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Al Bothwell graduated A.B. from Washington University in 1971 and received his PhD from Yale University in 1975 under the supervision of Sidney Altman. He completed his postdoctoral training at MIT with David Baltimore. Since joining the Immunobiology faculty at Yale Medical School in 1982, he has focused on understanding B cell antibody diversity and the structure and function of T cell receptors. His research has transitioned towards human immunity, employing humanized mouse models to investigate vascular diseases, transplantation, and type 1 diabetes. He has made significant contributions to the understanding of gut inflammation and has studied genetic tumor models of Inflammatory Bowel Disease, emphasizing the role of Wnt signaling in immune regulation. His work on the immunoregulatory properties of Wnt signaling is crucial for understanding how tissue permeability is influenced and lymphocyte mobility is affected in tumor environments.
Yale School of Medicine • New Haven, CT
Research activities include studies on B cell antibody diversity, T cell receptor signaling, and immunology with a focus on humanized mouse models.
Administered via the Graduate School of Arts and Sciences (GSAS). GRE General is optional for PhD.