Dr. Ali Khoshnan

Biography

Ali Khoshnan is an Associate Professor at the Keck School of Medicine of the University of Southern California. His research focuses on the molecular pathogenesis of Huntington's disease, a genetically inherited neurodegenerative disorder. Dr. Khoshnan's work involves the study of mutant huntingtin protein and its role in neurodegenerative processes. He employs human neurons, brain organoids, and various animal models, including mice and Drosophila, to investigate pathogenic assemblies and how they disrupt neuronal pathways. One of his key research interests lies in understanding how gut microbiota-gut-brain pathways contribute to the development of symptoms in Huntington's disease. His lab is also involved in the engineering of antibodies targeting pathogenic conformations of mutant huntingtin for diagnostic and therapeutic applications. Khoshnan has published extensively on topics related to Huntington's disease, including studies that delve into metabolic changes in mouse models and the regulation of brain development genes by mutant huntingtin. He aims to develop gut-based therapies for Huntington's disease based on his findings.

Research Interests

Experience