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Alice started her scientific research career at the University of Manchester, where she completed her PhD in Molecular Genetics and Cell Biology, investigating the role of bestrophin-1 in ocular disease. Her doctoral studies made a significant contribution to the field by elucidating the underlying mechanisms of diseases and deciphering phenotype-genotype correlations. In her postdoctoral position at University College London's Institute of Ophthalmology, Alice focused on identifying novel genetic causes of autosomal recessive retinal diseases by exploiting homozygosity mapping in consanguineous pedigrees alongside new developments in generation sequencing methods. Her research led to the identification of six novel genetic causes of ocular conditions, including Leber's congenital amaurosis and retinitis pigmentosa. She later investigated the genetics of complex monogenic corneal diseases and developed a special interest in inherited corneal disease mechanisms, receiving the Fight for Sight Early Career Investigator Award in 2015. Currently, Alice's research program at the Institute of Ophthalmology aims to identify the genetic origins and mechanisms underlying inherited corneal diseases to facilitate the development of innovative diagnostics and therapies. Since initiating her group in 2015, she has been awarded £3.5 million in funding from research councils, charities, and the biotech sector, and has received highly competitive personal fellowships, including the UKRI Future Leaders Fellowship.
University College London • United Kingdom
Leading research on genetic causes of ocular and corneal diseases.
Moorfields Eye Hospital NHS Foundation Trust • London, United Kingdom
Conducting research in collaboration with the NHS on ocular conditions.