Dr. Alice Denton

Biography

Alice Denton completed her PhD in Melbourne, Australia, under the supervision of Professors Peter Doherty and Stephen Turner, where she investigated how CD8 T cells combat viral infections. She then moved to the UK to collaborate with Professor Doug Fearon at the University of Cambridge on the study of lymphoid fibroblasts, making significant discoveries regarding their role in regulating immune homeostasis and generating adaptive immunity. Subsequently, she worked with Dr. Michelle Linterman at the Babraham Institute, where her research focused on the developmental origins of lymphoid fibroblasts and the role of pulmonary fibroblasts in promoting local immunity during viral infections. Aging's impact on fibroblast function and support of immune responses was a key aspect of her work. In January 2020, she joined Imperial College London, where her research continues to explore how fibroblasts contribute to the generation and maintenance of adaptive immune responses, with particular interest in germinal center reactions and their coordination in generating long-lived, high-affinity antibodies necessary for effective vaccination, especially in older people. Denton's current investigations include assessing how vaccine formulations affect lymph node fibroblast function and their role in initiating and maintaining germinal center responses.

Research Interests

Experience