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Alicia Darnell is an Assistant Professor in the Department of Pharmacology and Cancer Biology at Duke University. Her research focuses on the critical integration of protein synthesis with cellular metabolism and growth, emphasizing gene expression. The Darnell lab, set to open in September 2024, investigates the relationship between amino acid metabolism and protein synthesis in cancer cells. The lab aims to understand how amino acid limitations lead to codon-specific ribosome stalling and premature fall-off, inhibiting protein production. Through various genetic and biochemical techniques, such as fluorescent reporter development, ribosome profiling, charged tRNA sequencing, and mass spectrometry for metabolites and proteins, the team explores the direct control of gene expression by amino acid physiology and tRNA pool dynamics. Alicia is currently looking to hire graduate students, research technicians, and postdoctoral researchers interested in these areas.
Department of Pharmacology & Cancer Biology • Durham, NC
Instructor in the Department of Pharmacology and Cancer Biology at Duke University.
Department of Biomedical Engineering (MS program)