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Alicia Darnell is an Assistant Professor in the Department of Pharmacology and Cancer Biology at the Duke Cancer Institute. Her research focuses on protein synthesis and its critical integration point within cellular metabolism, growth, and gene expression. The Darnell lab, which is set to open in September 2024, investigates the relationship between amino acid metabolism and protein synthesis in cancer cells, particularly how amino acid limitation can lead to codon-specific ribosome stalling and premature fall-off, inhibiting protein production. The lab employs a variety of genetic and biochemical techniques, including fluorescent reporter development, ribosome profiling, charged tRNA sequencing, and metabolite/protein mass spectrometry, to explore the direct control of gene expression through amino acid physiology and tRNA pool dynamics. Darnell is actively seeking graduate students, research technicians, and postdoctoral researchers interested in joining her lab to discuss the ongoing research and available positions.
Duke Cancer Institute • Durham, NC
Joining the Duke Cancer Institute as an Assistant Professor in the Department of Pharmacology and Cancer Biology.
Department of Biomedical Engineering (MS program)