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Alyson Fournier's research focuses on cellular and molecular mechanisms regulating axon degeneration and regeneration. In the context of the central nervous system, neurons that experience traumatic injury or neurodegenerative conditions fail to repair spontaneously. This abortive regenerative response is attributed to the failure of injured neurons to initiate a growth program, often constrained by an inhibitory growth environment. The aim of Fournier's research program is to enhance the understanding of the molecular signaling pathways that influence neuronal responses following traumatic injury and exposure to inflammatory insults, which are commonly encountered in multiple sclerosis. Current projects are centered on elucidating the roles of microRNAs and 14-3-3 adaptor proteins in mediating neuronal responses to injury. A fuller understanding of these neuronal responses is essential for the development of strategies that promote neuroprotection and encourage neuronal regeneration.
Department: Department of Medicine. Program: Experimental Medicine.