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Professor Amanda Fisher focuses on the molecular interplay of DNA-binding proteins and chromatin states to determine heritable gene silencing and inducible activation. Her research explores how epigenetic inheritance affects cell identity, specifically during cell division where DNA functions need to be specialized through differential gene expression. This process relies on transcription factors, epigenetic regulators, non-coding RNAs, modified histones, and DNA methylation to maintain the identity of cells as they divide. Using a variety of genetic and cell biology tools, she investigates the epigenetic mechanisms that regulate gene expression and how alterations can lead to disease. Her long-term goal is to understand how epigenetic information is transmitted during cell division and the maintenance of mitotic chromosomes. Additionally, she develops convergent molecular and proteomic imaging approaches to examine the repertoire of factors associated with these chromosomes. Fisher's laboratory at the University of Oxford is involved in innovative research on cellular identity and gene regulation.
Department of Politics and International Relations - Higher Level English requirement.