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Amanda Garner, PhD, is a Charles Walgreen Jr Professor of Medicinal Chemistry at the University of Michigan College of Pharmacy and the Director of the Interdepartmental Program in Medicinal Chemistry. Her research focuses on the roles of non-coding RNAs, including microRNAs and long non-coding RNAs, which play fundamental roles in health and disease. The completion of the human genome project revealed that a vast majority of the genome encodes non-coding RNAs, leading to a renaissance in RNA biology and its implications in medicine. Garner’s work aims to uncover the connections between aberrant regulation of these RNAs and various human pathologies, including neurodegenerative diseases, cancer, and metabolic disorders. She is pioneering approaches that target coding messenger RNAs (mRNAs) to develop new therapeutic strategies for undruggable protein targets. Her lab is also exploring bacterial RNAs and RNA viruses as potential drug targets for new infectious disease agents. Her interdisciplinary research bridges chemistry and biology, focusing on high-throughput screening technologies for RNA-related drug discovery. Projects in her lab vary from rational drug design to the elucidation of RNA-drug interactions, all aimed at leading to the development of next-generation medicines that can improve human health.
Department of Electrical Engineering and Computer Science