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Amelia Escolano, Ph.D., is an Assistant Professor in the Biomedical Graduate Studies at the Perelman School of Medicine, University of Pennsylvania, and conducts her research at the Wistar Institute. Her laboratory focuses on HIV-1 immunization strategies, investigating the elicitation of broadly neutralizing antibodies (bNAbs) through sequential immunization protocols. Dr. Escolano's work demonstrated that common vaccination strategies require modifications to elicit highly mutated bNAbs, emphasizing the significance of engineered envelope immunogens. Her research aims to establish guidelines for vaccine design to manipulate the immunodominance of antibody responses, targeting conserved epitopes sensitive to neutralization. She employs advanced single-cell analysis to study antibody maturation and the immune response in various animal models. Dr. Escolano's lab has extensive experience in isolating specific B cells from diverse immunized subjects, contributing valuable insights into vaccine design against complex pathogens like HIV-1.
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