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Amy Fraley’s cross-disciplinary research program centers on natural products biosynthesis, combining foundational evolutionary questions with novel biotechnology applications. Her work focuses on understanding enzymatic chemistry and tuning selective biochemical transformations, aiming to provide sustainable sources of bioactive metabolites and viable therapeutics to better understand disease mechanisms. Fraley's research spans the interface of life and pharmaceutical sciences while addressing pressing questions of environmental sustainability. After earning her B.Sc. in Chemistry from Millersville University of Pennsylvania in 2014, she completed her Ph.D. in Medicinal Chemistry at the University of Michigan in 2019. There, she characterized enzymes involved in fungal indole alkaloid biosynthesis and discovered a new family of zinc-binding flavin-dependent halogenases. Her subsequent postdoctoral research at ETH Zürich under Prof. Jörn Piel focused on the biosynthesis of anticancer polyketides from marine symbiotic bacteria. In January 2024, she became an Assistant Professor of Medicinal Chemistry at ETH Zürich in the Department of Chemistry and Applied Biosciences, where she continues to advance research and education in her field.
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