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Professor Keating studied physics as an undergraduate at Harvard College and obtained her Ph.D. in 1998 from the University of California, Los Angeles. During her graduate work, she applied computational and experimental methods from physical organic chemistry to study carbene reaction mechanisms. After completing her Ph.D., she began her research on protein interactions as a postdoctoral fellow at the Whitehead Institute and the MIT Chemistry Department. In 2002, she became a member of the MIT Biology Department and joined the Department of Biological Engineering in 2014. In 2023, she was named head of the MIT Department of Biology. Her lab focuses on understanding, in high detail, the interaction properties of proteins, encoded sequences, and structures, with a particular emphasis on protein families that are important for human health, such as α-helical coiled coil Bcl-2 family apoptosis-regulating proteins.