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Amy M. Weeks is an Assistant Professor in the Department of Chemistry at the University of Wisconsin–Madison. Her research focuses on spatially resolved mapping of post-translational modifications (PTMs), protein engineering, and chemoproteomics. Utilizing advanced mass spectrometry techniques, her lab aims to identify and understand the functional roles of various PTMs that regulate biological processes. By repurposing native enzymes as chemical biology tools, her research enhances the spatial and temporal resolution of studying PTMs. Dr. Weeks's work addresses significant challenges in cataloging modifications to assign biological functions, bridging gaps in proximity labeling and proteomic studies. Her contributions are expected to provide critical insights into the dynamic nature of proteomes and their implications for human health, disease progression, and developmental biology. Additionally, she is keen on developing chemoenzymatic tools to facilitate the global analysis of proteolysis and phosphorylation, highlighting their importance in cell signaling and therapeutic strategies.
Department: Department of Computer Sciences