Dr. Anastasios Karadimitris

Biography

Anastasios Karadimitris's laboratory focuses on three key areas of research: first, the molecular and cellular pathogenesis of multiple myeloma and mature B cell malignancies. His specific interests include the delineation and characterization of myeloma propagating cells and the role of transcription factor deregulation in the pathogenesis of multiple myeloma, particularly in understanding the mechanisms behind osteoclast activation and bone disease associated with myeloma. The second area of research involves the biology of glycolipid-specific T cells and their role in haematological disease, exploring the therapeutic potential of invariant NKT cells in allogeneic stem cell transplantation and the role of glycosylphosphatidylinositol-specific T cells in the pathogenesis of paroxysmal nocturnal haemoglobinuria. The third focus is on understanding the transcriptional and epigenetic basis of housekeeping gene regulation and its therapeutic implications for autosomal recessive Mendelian diseases, employing inherited GPI deficiency disorders and glycolytic pathway disease models. His work integrates a variety of molecular and cell biology tools, genomics, advanced flow cytometry, and animal models, increasingly interpreting research through systems biology approaches in collaboration with Prof. Michael Stumpf's group at Imperial College. Anastasios also participates in leading local Phase III clinical trials in conjunction with the pharmaceutical industry, focusing on developing capacity for early Phase I/II clinical trials in lymphoma and myeloma.

Research Interests

Experience