Dr. Andi Mcclatchey

Biography

Andi McClatchey is a professor in the Department of Pathology at Massachusetts General Hospital, focusing on the organization and function of protein complexes in the cell cortex and their contributions to morphogenesis and tumorigenesis. The laboratory aims to unravel the regulatory mechanisms by which these protein complexes influence membrane receptors and the cytoskeleton, thereby affecting cellular architecture. Key areas of research involve the NF2 tumor suppressor protein, Merlin, and its interactions with related ERM proteins, which are critical for linking membrane proteins to the actin cytoskeleton. McClatchey's work includes generating and analyzing mouse models to understand the roles of Merlin and ERMs in cellular processes and tumor development, particularly in tissues such as the liver, kidney, and skin. The laboratory's research suggests that genetic mutations in the NF2 gene are implicated in familial cancers, contributing to the growth of nervous system tumors. Current studies aim to elucidate the mechanistic details of cortical protein complex assembly and distribution, which are vital for understanding tumor growth and progression.

Research Interests

Experience