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Andrea Califano is the Clyde Helen Wu Professor of Chemical Systems Biology at Columbia University, where he also serves as the Director of the JP Sulzberger Columbia Genome Center and Co-Leader of the Precision Oncology Systems Biology Program at the Herbert Irving Comprehensive Cancer Center. With a background as a physicist, Dr. Califano has made significant contributions to the field of systems biology, focusing on the complex molecular interactions that drive cancer progression and drug resistance at the single-cell level. His innovative research has shifted cancer studies from an exclusive focus on gene mutations to an analysis of tumor-specific regulatory networks, identifying master regulator proteins that are critical in tumorigenesis. He has developed methodologies that integrate computational and experimental approaches to reconstruct the regulatory signaling logic of human cells on a genome-wide scale. Dr. Califano's work has led to advances in precision medicine, demonstrating how tailored therapies targeting master regulators can improve treatment outcomes for patients with aggressive malignancies. His research is supported by numerous institutions including the National Cancer Institute and has resulted in clinical trials that explore the efficacy of novel therapeutic hypotheses.
Department of Anthropology (GSAS)