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Andrea Califano is a professor at the Department of Systems Biology, Columbia University, specializing in Chemical and Systems Biology. He is the founding chair of the Department of Systems Biology, where he integrates computational and experimental methodologies to reconstruct regulatory signaling logic in human cells. His pioneering work focuses on identifying the molecular factors that contribute to cancer progression and drug resistance at the single-cell level. By redirecting cancer research from merely gene mutations to complex tumor-specific molecular interaction networks, his lab has discovered master regulator proteins that drive tumor behaviors and dependencies, offering novel therapeutic targets. Dr. Califano's research has led to clinical trials for several aggressive malignancies, including metastatic neuroendocrine tumors and inflammatory breast cancer, demonstrating significant contributions to precision medicine. His work is supported by various prestigious institutions, including the National Cancer Institute and the Prostate Cancer Foundation, and he serves in leadership roles in multiple scientific organizations and editorial boards.
Columbia University • New York, NY
Professor of Chemical and Systems Biology, director of the JP Sulzberger Columbia Genome Center.
Department of Anthropology (GSAS)