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Andrea Piunti studies the deregulation of chromatin biology and its contributions to cancer onset and progression. His lab focuses on Polycomb group (PcG) proteins, which are prominent regulators of chromatin. These proteins serve as master regulators of mammalian development and cellular proliferation, primarily exerting their function through transcriptional repression achieved via chromatin activity. Deregulated activities of PcG proteins in cancer play significant roles in oncogenic processes, specifically concerning rare pediatric brain tumors such as diffuse midline gliomas (DMG) and posterior fossa group (PFA) ependymomas. Piunti's research aims to elucidate how the deregulation of PcG proteins in tumors contributes to the emergence and dissemination of these rare malignancies.
University of Chicago • Chicago, IL
Researching the roles of chromatin biology in cancer onset and progression.
Department of Philosophy