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Andrei Thomas-Tikhonenko is a professor in the Department of Pathology and Laboratory Medicine at the University of Pennsylvania's Perelman School of Medicine. He received his BSc in Biochemistry/Virology from Moscow State University in 1984 and earned his PhD in Oncology/Virology from the Russian Academy of Medical Sciences in 1988. His laboratory specializes in the pathobiology of solid hematopoietic malignancies, particularly lymphomas and leukemias influenced by MYC overexpression. His current research centers on the role of non-coding RNAs in cancer pathogenesis and therapeutic resistance, particularly focusing on mechanisms of neoplastic transformation related to Myc family oncoproteins. Thomas-Tikhonenko has made significant contributions to understanding the regulation of microRNAs linked to tumor growth and resistance to therapies, significantly impacting approaches to immunotherapy in pediatric cancers. The lab is a key player in various translational research initiatives aimed at developing cutting-edge immunotherapeutics targeting pediatric cancers. His recent work has unveiled novel splicing variants that could provide unique cancer-specific targets for future therapies.
Perelman School of Medicine, University of Pennsylvania • Philadelphia, PA
Researches pathobiology of hematopoietic malignancies and leads a laboratory focusing on cancer research.
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