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Andrew G. Clark is a population geneticist whose research focuses on empirical analytical problems associated with genetic variation in populations. His projects are centered on the genetic basis of complex traits, particularly understanding the gene regulatory networks underlying these traits. By selecting phenotypes that provide good information about the governing gene regulatory networks, he investigates how variations within these networks are manifested as phenotypic variations. His work primarily involves collecting data at the single nucleotide polymorphism (SNP) level of gene expression to test properties of variation prescribed by population genetics theory. He also studies the genetic perturbations and natural variation lines through RNAi and environmental factors such as bacterial infections, which lend specificity to the inferences drawn from models that connect genotype to phenotype. His research includes systems involving humans and Drosophila, with a focus on cardiovascular disease risk and genomic imprinting. Additionally, he oversees a Drosophila laboratory where students research various genetic and evolutionary basis variations.
Department of Architecture