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The Koh lab focuses on understanding the design principles of immune development that allow flexibility in cellular fate and function, as well as the mechanisms that are subverted in human disease. A major emphasis is on identifying determinants that allow thymic epithelia to ectopically express thousands of tissue-specific self-antigens, such as insulin, to promote tolerance to harmful self-reactive T cells and prevent autoimmunity, including diabetes. The lab's research is centered around understanding how T cells acquire competence and deploy diverse arrays of effector functions, with a particular focus on how plasticity relates to leukemogenesis. The lab employs a broad, interdisciplinary approach, combining genetics, genomics, biochemistry, and proteomics, with a specific investment in developing multi-omics methods to interrogate chromatin, gene expression, and cell-surface proteins at the single-cell level. The goal is to elucidate cellular plasticity during programmed development and in dysregulated disease, thereby availing novel therapeutic avenues for human disorders.
University of Chicago • Chicago, IL
Department of Philosophy