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Andrew Seung-Hyun Koh is an Assistant Professor in the Department of Pathology at the University of Chicago. His research interests lie at the intersection of immunology and cancer biology, focusing on how the immune system can tolerate self while responding effectively to pathogens. Koh's lab investigates the design principles governing immune development, with a particular emphasis on understanding how thymic epithelial cells can ectopically express tissue-specific self-antigens to promote tolerance and prevent autoimmune diseases like diabetes. He employs a broad interdisciplinary approach, integrating genetics, genomics, biochemistry, and proteomics, with a strong investment in developing multi-omics methods to interrogate chromatin and gene expression at the single-cell level. His work on T cell plasticity and differentiation has opened new therapeutic avenues for human disorders, showcasing the importance of understanding immune mechanisms in the context of human disease.
Department of Philosophy