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Andrew Kruse is a Professor in the Department of Biological Chemistry & Molecular Pharmacology at Harvard University. He focuses on elucidating the molecular basis of membrane protein signaling, employing techniques from protein engineering to structural biology and pharmacology. His research is centered on the role of signal transduction in cell membranes, which is crucial for human physiology and disease. He particularly studies G protein-coupled receptors (GPCRs), which are pivotal in regulating neurotransmission, metabolic homeostasis, and cardiovascular functions. Understanding the molecular mechanisms of GPCR signaling is key to developing therapeutic drugs. His lab aims to harness insights from structural biology and biophysical methods to study model GPCRs, particularly muscarinic acetylcholine receptors. Furthermore, Kruse is interested in exploring less studied signal transduction pathways and their regulatory roles in human metabolic homeostasis, with a long-term goal of developing new therapeutics.
Administered by the Harvard Kenneth C. Griffin Graduate School of Arts and Sciences (GSAS).