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Andrew Mesecar is a Distinguished Professor of Biochemistry at Purdue University, where he also serves as the Walther Professor of Cancer Structural Biology and the Robert W. Miller Director of the Purdue Institute for Cancer Research. His research primarily focuses on the structure and function of enzymes that are critically involved in diseases such as cancer, Alzheimer’s, and infections caused by coronaviruses. Mesecar's lab employs an integrated approach utilizing advanced experimental techniques from chemistry, biology, and physics to gain a deeper understanding of enzymatic processes. This includes the use of static and time-resolved X-ray crystallography, enzyme kinetics, molecular biology techniques, mass-spectrometry-based proteomics, and high-throughput screening. His work aims to elucidate the molecular mechanisms behind disease processes and to leverage this knowledge for the design and development of small molecule drugs.
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