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Andrew J Modzelewski is an Assistant Professor in the Perelman School of Medicine at the University of Pennsylvania. His research primarily focuses on retrotransposon reactivation in developmental biology, with particular interest in the role of these elements in disease and genome evolution. His lab, the Modz Lab, investigates how retrotransposons, which constitute a significant portion of the human genome, can influence gene regulation and contribute to important biological processes such as memory plasticity and the development of the placenta. Modzelewski's work also explores the mechanisms that lead to the intentional and unintentional reactivation of retrotransposons during different stages of development, including the implications for aging and cancer. The research aims to improve understanding of these elements, leveraging advanced genome editing technologies to study their functions more effectively.
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