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Andrew Santiago-Frangos is a postdoctoral researcher in the Department of Biology at the University of Pennsylvania. He holds a BSc in Biochemistry from the University of Leicester and a Ph.D. in Cell, Molecular, and Developmental Biology from Johns Hopkins University. His research focuses on the mechanisms and applications of bacterial and archaeal CRISPR adaptive immune systems. Specifically, he investigates how these systems use DNA-based memories of past phage infections to regulate immune responses. His work delves into how CRISPR-generated nucleotide messengers can signal immune pathways, thereby influencing diverse biochemical cascades. Additionally, Santiago-Frangos has co-invented an innovative RNA-guided system for sensitive detection of SARS-CoV-2 RNA. His selected publications demonstrate his contributions to the field, including insights into genome folding necessary for site-specific integration of foreign DNA and advancements in amplification-free diagnostics using CRISPR-Cas systems.
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