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Over a decade, members of the van Eps Laboratory have recognized key differences and similarities in the initial events that lead to types of laminitis: Sepsis-related laminitis (SRL), Endocrinopathic laminitis (associated with insulin dysregulation/hyperinsulinemia), and Supporting limb laminitis (SLL). The focus is on the early events leading to an understanding of how laminitis occurs in clinical situations, helping to identify therapeutic targets. The goal is to identify the key pathophysiological events that lead to forms of laminitis and develop clinically applicable means of preventing this crippling equine disease.
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