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Angela Koehler is the Charles W. Jennifer C. Johnson Professor at the Massachusetts Institute of Technology in the Department of Biological Engineering. Her research focuses on developing chemical tools and technologies for drug discovery, particularly targeting proteins that are considered 'undruggable.' Angela received her B.A. in Biochemistry and Molecular Biology from Reed College in 1997, where she conducted structural biochemical studies under the guidance of Professor Arthur Glasfeld. She earned her PhD in Chemistry from Harvard University in 2003, working with Professor Stuart Schreiber to develop novel technologies for identifying and characterizing interactions between proteins and small molecules. After her doctoral studies, she became an Institute Fellow in the Chemical Biology Program at the Broad Institute and was a Group Leader in the NCI Initiative for Chemical Genetics. Angela has led projects targeting causal cancer genes through small molecules, emphasizing the importance of transcriptional regulation in disease development, particularly in cancer.